Enables RNA uridylyltransferase activity and miRNA binding activity. Involved in RNA metabolic process and transposable element silencing by mRNA destabilization. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TUT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:86,098,791–86,100,295 | 254.9 kb | Distal (>10kb) Multiome | 436 | |
| chr9:86,118,248–86,119,118 | 235.9 kb | Distal (>10kb) Multiome | 10 | |
| chr9:86,126,993–86,127,913 | 226.9 kb | Distal (>10kb) Multiome | 439 | |
| chr9:86,186,986–86,187,492 | 167.2 kb | Distal (>10kb) Multiome | 90 | |
| chr9:86,281,630–86,283,173 | 71.9 kb | Distal (>10kb) Multiome | 959 | |
| chr9:86,353,702–86,354,978 | 92 bp | At TSS Multiome | 1008 | |
| chr9:86,491,030–86,491,730 | 137.1 kb | Distal (>10kb) Multiome | 79 |
Genomic view of the TUT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.