This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TUSC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUSC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUSC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:25,668,937–25,669,382 | 9.1 kb | Proximal (<10kb) | 6 | |
| chr9:25,674,250–25,674,383 | 4.1 kb | Proximal (<10kb) | 4 | |
| chr9:25,674,551–25,675,222 | 3.2 kb | Proximal (<10kb) | 6 | |
| chr9:25,675,944–25,676,320 | 2.1 kb | Proximal (<10kb) | 9 | |
| chr9:25,677,338–25,678,873 | at TSS | At TSS | 505 |
Genomic view of the TUSC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.