Enables ATPase binding activity. Involved in endoplasmic reticulum calcium ion homeostasis and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TUNAR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUNAR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUNAR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:95,714,059–95,714,626 | 162.1 kb | Distal (>10kb) Multiome | 151 | |
| chr14:95,875,877–95,877,410 | 17 bp | At TSS Multiome | 313 | |
| chr14:95,957,840–95,959,022 | 82.3 kb | Distal (>10kb) Multiome | 23 | |
| chr14:95,968,138–95,968,704 | 92.1 kb | Distal (>10kb) Multiome | 71 | |
| chr14:95,981,031–95,981,711 | 105.0 kb | Distal (>10kb) Multiome | 18 | |
| chr14:95,993,727–95,994,325 | 117.7 kb | Distal (>10kb) Multiome | 120 | |
| chr14:96,038,923–96,040,144 | 162.9 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the TUNAR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.