Predicted to be involved in protein ubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TULP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TULP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TULP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:157,981,020–157,982,539 | 250.5 kb | Distal (>10kb) Multiome | 932 | |
| chr6:158,167,710–158,168,897 | 63.9 kb | Distal (>10kb) Multiome | 961 | |
| chr6:158,231,543–158,233,134 | 104 bp | At TSS Multiome | 898 | |
| chr6:158,339,091–158,339,595 | 107.2 kb | Distal (>10kb) Multiome | 264 | |
| chr6:158,464,343–158,464,804 | 232.4 kb | Distal (>10kb) Multiome HiCAR | 90 | |
| chr6:158,467,569–158,468,415 | 235.8 kb | Distal (>10kb) Multiome HiCAR | 239 | |
| chr6:158,611,556–158,612,449 | 379.6 kb | Distal (>10kb) Multiome HiCAR | 166 |
Genomic view of the TULP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.