Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in intercellular bridge; microtubule; and mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TUBB6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUBB6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUBB6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:12,038,383–12,039,391 | 269.2 kb | Distal (>10kb) Multiome | 700 | |
| chr18:12,076,413–12,076,882 | 231.6 kb | Distal (>10kb) Multiome | 129 | |
| chr18:12,253,776–12,254,799 | 54.0 kb | Distal (>10kb) Multiome | 162 | |
| chr18:12,271,329–12,272,193 | 36.4 kb | Distal (>10kb) Multiome | 601 | |
| chr18:12,287,265–12,288,653 | 20.7 kb | Distal (>10kb) Multiome | 353 | |
| chr18:12,288,796–12,289,337 | 19.2 kb | Distal (>10kb) Multiome | 159 | |
| chr18:12,307,278–12,309,118 | 64 bp | At TSS Multiome | 646 | |
| chr18:12,376,065–12,378,406 | 69.2 kb | Distal (>10kb) Multiome | 1012 | |
| chr18:12,407,513–12,408,521 | 99.7 kb | Distal (>10kb) Multiome | 637 | |
| chr18:12,419,774–12,420,625 | 111.9 kb | Distal (>10kb) Multiome | 579 | |
| chr18:12,420,869–12,421,324 | 112.8 kb | Distal (>10kb) Multiome | 417 |
Genomic view of the TUBB6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.