This gene encodes a non-coding RNA transcribed from the opposite strand to the titin gene. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for TTN-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTN-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTN-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:178,413,219–178,414,399 | 109.5 kb | Distal (>10kb) Multiome | 734 | |
| chr2:178,414,525–178,415,185 | 108.3 kb | Distal (>10kb) Multiome | 748 | |
| chr2:178,450,146–178,452,280 | 72.1 kb | Distal (>10kb) Multiome | 1097 | |
| chr2:178,477,968–178,479,684 | 44.4 kb | Distal (>10kb) Multiome | 943 | |
| chr2:178,479,849–178,481,204 | 42.8 kb | Distal (>10kb) Multiome | 786 | |
| chr2:178,522,788–178,524,094 | 33 bp | At TSS Multiome | 612 |
Genomic view of the TTN-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.