Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC7B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC7B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC7B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:90,399,397–90,399,863 | 416.8 kb | Distal (>10kb) Multiome HiCAR | 555 | |
| chr14:90,605,311–90,605,782 | 210.9 kb | Distal (>10kb) Multiome | 80 | |
| chr14:90,758,006–90,759,215 | 58.0 kb | Distal (>10kb) Multiome | 568 | |
| chr14:90,816,013–90,817,051 | 2 bp | At TSS Multiome | 233 | |
| chr14:90,827,894–90,828,472 | 11.8 kb | Distal (>10kb) Multiome | 550 | |
| chr14:91,059,736–91,061,424 | 244.4 kb | Distal (>10kb) Multiome | 848 | |
| chr14:91,113,925–91,114,783 | 297.7 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the TTC7B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.