Predicted to be involved in cilium assembly and otolith morphogenesis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC39C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC39C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC39C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:23,721,611–23,722,408 | 292.4 kb | Distal (>10kb) Multiome | 82 | |
| chr18:23,918,141–23,918,930 | 95.9 kb | Distal (>10kb) Multiome | 200 | |
| chr18:23,938,974–23,939,515 | 75.2 kb | Distal (>10kb) Multiome | 48 | |
| chr18:24,014,017–24,015,501 | 3 bp | At TSS Multiome | 619 | |
| chr18:24,138,655–24,139,879 | 124.7 kb | Distal (>10kb) Multiome | 483 | |
| chr18:24,176,686–24,177,648 | 162.8 kb | Distal (>10kb) Multiome | 194 | |
| chr18:24,271,142–24,272,382 | 257.6 kb | Distal (>10kb) Multiome | 485 |
Genomic view of the TTC39C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.