Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:36,965,990–36,967,232 | 106.6 kb | Distal (>10kb) Multiome | 770 | |
| chr21:36,989,570–36,990,911 | 83.2 kb | Distal (>10kb) Multiome | 1026 | |
| chr21:37,006,026–37,007,215 | 66.7 kb | Distal (>10kb) Multiome | 280 | |
| chr21:37,041,546–37,042,235 | 31.2 kb | Distal (>10kb) Multiome | 119 | |
| chr21:37,072,329–37,074,488 | 177 bp | At TSS Multiome | 994 | |
| chr21:37,220,678–37,221,494 | 147.9 kb | Distal (>10kb) Multiome | 881 | |
| chr21:37,257,305–37,258,840 | 184.9 kb | Distal (>10kb) Multiome | 787 | |
| chr21:37,266,801–37,268,388 | 194.3 kb | Distal (>10kb) Multiome | 1079 | |
| chr21:37,365,724–37,368,330 | 293.2 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the TTC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.