Predicted to enable transferase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSTD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSTD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSTD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,386,832–97,387,759 | 246.2 kb | Distal (>10kb) Multiome | 555 | |
| chr9:97,411,603–97,412,682 | 221.3 kb | Distal (>10kb) Multiome HiCAR | 864 | |
| chr9:97,436,823–97,437,760 | 195.9 kb | Distal (>10kb) Multiome | 98 | |
| chr9:97,501,163–97,503,374 | 131.9 kb | Distal (>10kb) Multiome | 581 | |
| chr9:97,528,160–97,528,802 | 104.9 kb | Distal (>10kb) Multiome | 118 | |
| chr9:97,598,751–97,599,712 | 34.3 kb | Distal (>10kb) Multiome | 274 | |
| chr9:97,632,371–97,634,267 | 83 bp | At TSS Multiome | 1027 | |
| chr9:97,696,750–97,697,733 | 64.0 kb | Distal (>10kb) Multiome | 836 | |
| chr9:97,710,703–97,711,693 | 77.9 kb | Distal (>10kb) Multiome | 257 | |
| chr9:97,741,053–97,741,796 | 108.0 kb | Distal (>10kb) Multiome | 305 | |
| chr9:97,803,235–97,804,055 | 170.2 kb | Distal (>10kb) Multiome | 679 | |
| chr9:97,853,103–97,855,002 | 220.6 kb | Distal (>10kb) Multiome | 323 | |
| chr9:97,922,022–97,923,085 | 289.0 kb | Distal (>10kb) Multiome | 1110 |
Genomic view of the TSTD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.