Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSPYL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPYL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPYL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:116,100,248–116,101,958 | 153.2 kb | Distal (>10kb) Multiome | 1010 | |
| chr6:116,145,874–116,146,681 | 107.8 kb | Distal (>10kb) Multiome | 187 | |
| chr6:116,229,156–116,229,872 | 24.6 kb | Distal (>10kb) Multiome | 151 | |
| chr6:116,253,243–116,254,510 | 8 bp | At TSS Multiome | 816 | |
| chr6:116,279,028–116,280,325 | 25.8 kb | Distal (>10kb) Multiome | 994 | |
| chr6:116,370,005–116,371,990 | 116.8 kb | Distal (>10kb) Multiome | 655 | |
| chr6:116,461,655–116,462,775 | 208.2 kb | Distal (>10kb) Multiome | 421 |
Genomic view of the TSPYL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.