The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for TSPYL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPYL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPYL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:116,100,248–116,101,958 | 179.0 kb | Distal (>10kb) Multiome | 1010 | |
| chr6:116,145,874–116,146,681 | 133.6 kb | Distal (>10kb) Multiome | 187 | |
| chr6:116,229,156–116,229,872 | 50.4 kb | Distal (>10kb) Multiome | 151 | |
| chr6:116,253,243–116,254,510 | 25.8 kb | Distal (>10kb) Multiome | 816 | |
| chr6:116,271,230–116,271,585 | 8.3 kb | Proximal (<10kb) | 36 | |
| chr6:116,279,028–116,280,325 | 15 bp | At TSS Multiome | 994 | |
| chr6:116,287,768–116,288,188 | 7.9 kb | Proximal (<10kb) | 123 | |
| chr6:116,370,005–116,371,990 | 91.0 kb | Distal (>10kb) Multiome | 655 | |
| chr6:116,461,655–116,462,775 | 182.4 kb | Distal (>10kb) Multiome | 421 | |
| chr6:116,570,743–116,571,945 | 291.4 kb | Distal (>10kb) Multiome HiCAR | 1041 | |
| chr6:116,615,808–116,617,150 | 336.5 kb | Distal (>10kb) Multiome HiCAR | 493 | |
| chr6:116,680,569–116,682,340 | 401.2 kb | Distal (>10kb) Multiome HiCAR | 965 |
Genomic view of the TSPYL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.