Involved in regulation of sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSPAN18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPAN18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPAN18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:44,496,366–44,496,899 | 230.4 kb | Distal (>10kb) Multiome | 57 | |
| chr11:44,559,266–44,559,748 | 167.4 kb | Distal (>10kb) Multiome | 227 | |
| chr11:44,564,348–44,566,259 | 161.5 kb | Distal (>10kb) Multiome | 608 | |
| chr11:44,621,147–44,621,658 | 105.6 kb | Distal (>10kb) Multiome HiCAR | 430 | |
| chr11:44,725,781–44,728,323 | 1.0 kb | Proximal (<10kb) Multiome | 573 | |
| chr11:44,761,126–44,761,961 | 34.5 kb | Distal (>10kb) Multiome | 179 | |
| chr11:44,823,949–44,825,281 | 97.5 kb | Distal (>10kb) Multiome | 179 | |
| chr11:44,862,158–44,862,936 | 135.5 kb | Distal (>10kb) Multiome HiCAR | 435 | |
| chr11:44,893,997–44,894,680 | 167.4 kb | Distal (>10kb) Multiome HiCAR | 245 | |
| chr11:44,911,150–44,911,857 | 184.6 kb | Distal (>10kb) Multiome HiCAR | 202 | |
| chr11:44,949,162–44,951,290 | 222.7 kb | Distal (>10kb) Multiome | 458 | |
| chr11:44,954,146–44,954,620 | 227.4 kb | Distal (>10kb) Multiome | 48 | |
| chr11:44,977,463–44,978,182 | 250.8 kb | Distal (>10kb) Multiome | 120 |
Genomic view of the TSPAN18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.