The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TSPAN13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPAN13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPAN13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:16,511,401–16,512,647 | 241.6 kb | Distal (>10kb) Multiome | 110 | |
| chr7:16,587,596–16,588,471 | 165.8 kb | Distal (>10kb) Multiome | 148 | |
| chr7:16,644,616–16,647,076 | 107.8 kb | Distal (>10kb) Multiome | 1028 | |
| chr7:16,744,722–16,745,132 | 8.6 kb | Proximal (<10kb) | 26 | |
| chr7:16,753,299–16,754,826 | 25 bp | At TSS Multiome | 780 | |
| chr7:16,762,229–16,762,737 | 8.5 kb | Proximal (<10kb) | 50 | |
| chr7:16,851,810–16,852,609 | 98.4 kb | Distal (>10kb) Multiome | 144 |
Genomic view of the TSPAN13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.