The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TSPAN12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPAN12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPAN12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:120,779,442–120,780,307 | 77.5 kb | Distal (>10kb) Multiome | 43 | |
| chr7:120,780,841–120,781,415 | 76.2 kb | Distal (>10kb) Multiome | 93 | |
| chr7:120,856,135–120,858,538 | 462 bp | At TSS Multiome | 789 | |
| chr7:120,863,123–120,863,272 | 5.8 kb | Proximal (<10kb) | 22 | |
| chr7:120,950,270–120,951,497 | 93.5 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the TSPAN12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.