Enables enzyme binding activity. Involved in establishment of protein localization to organelle. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSPAN10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPAN10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPAN10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,339,311–81,340,470 | 297.7 kb | Distal (>10kb) Multiome | 474 | |
| chr17:81,345,409–81,347,165 | 291.0 kb | Distal (>10kb) Multiome | 891 | |
| chr17:81,393,141–81,395,575 | 243.2 kb | Distal (>10kb) Multiome | 1168 | |
| chr17:81,396,480–81,397,832 | 239.8 kb | Distal (>10kb) Multiome | 646 | |
| chr17:81,481,258–81,481,865 | 155.6 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 152.8 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 149.2 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 124.3 kb | Distal (>10kb) Multiome | 1116 | |
| chr17:81,518,632–81,519,878 | 117.7 kb | Distal (>10kb) Multiome | 617 | |
| chr17:81,537,462–81,537,907 | 99.5 kb | Distal (>10kb) Multiome | 282 | |
| chr17:81,551,821–81,553,314 | 84.0 kb | Distal (>10kb) Multiome | 845 | |
| chr17:81,636,404–81,637,301 | 177 bp | At TSS Multiome | 946 | |
| chr17:81,648,048–81,648,550 | 11.1 kb | Distal (>10kb) Multiome | 88 | |
| chr17:81,652,970–81,653,572 | 16.0 kb | Distal (>10kb) Multiome | 188 | |
| chr17:81,666,251–81,667,166 | 29.5 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 46.7 kb | Distal (>10kb) Multiome | 926 | |
| chr17:81,702,879–81,703,868 | 66.2 kb | Distal (>10kb) Multiome | 981 | |
| chr17:81,711,721–81,712,812 | 75.0 kb | Distal (>10kb) Multiome | 1056 | |
| chr17:81,832,473–81,833,976 | 196.1 kb | Distal (>10kb) Multiome | 1015 | |
| chr17:81,859,762–81,861,595 | 223.6 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:81,868,421–81,868,978 | 231.4 kb | Distal (>10kb) Multiome | 577 | |
| chr17:81,869,000–81,872,289 | 234.1 kb | Distal (>10kb) Multiome | 1136 | |
| chr17:81,891,143–81,892,257 | 254.6 kb | Distal (>10kb) Multiome | 969 | |
| chr17:81,910,443–81,911,980 | 274.4 kb | Distal (>10kb) Multiome | 806 | |
| chr17:81,917,586–81,918,522 | 281.0 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,923,285–81,923,863 | 286.3 kb | Distal (>10kb) Multiome | 399 | |
| chr17:81,926,141–81,929,133 | 290.7 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 300.1 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the TSPAN10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.