Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in synaptic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSNARE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSNARE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSNARE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:142,210,348–142,211,174 | 192.3 kb | Distal (>10kb) Multiome | 73 | |
| chr8:142,402,231–142,404,149 | 55 bp | At TSS Multiome | 776 | |
| chr8:142,452,045–142,453,565 | 49.8 kb | Distal (>10kb) Multiome | 400 | |
| chr8:142,471,794–142,472,417 | 69.0 kb | Distal (>10kb) Multiome | 323 | |
| chr8:142,474,787–142,476,474 | 72.5 kb | Distal (>10kb) Multiome | 367 | |
| chr8:142,509,815–142,511,574 | 107.9 kb | Distal (>10kb) Multiome | 217 | |
| chr8:142,545,443–142,546,050 | 142.5 kb | Distal (>10kb) Multiome | 205 | |
| chr8:142,613,900–142,615,241 | 211.4 kb | Distal (>10kb) Multiome | 485 |
Genomic view of the TSNARE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.