Involved in negative regulation of cell cycle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSC22D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSC22D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSC22D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:150,130,019–150,131,345 | 277.8 kb | Distal (>10kb) Multiome | 166 | |
| chr3:150,165,261–150,165,994 | 242.6 kb | Distal (>10kb) Multiome | 106 | |
| chr3:150,215,844–150,216,844 | 192.0 kb | Distal (>10kb) Multiome | 265 | |
| chr3:150,407,694–150,411,095 | 82 bp | At TSS Multiome | 1058 | |
| chr3:150,545,562–150,547,264 | 138.3 kb | Distal (>10kb) Multiome | 992 | |
| chr3:150,599,511–150,600,247 | 191.6 kb | Distal (>10kb) Multiome | 405 | |
| chr3:150,602,900–150,604,229 | 195.0 kb | Distal (>10kb) Multiome | 999 | |
| chr3:150,703,274–150,704,319 | 295.6 kb | Distal (>10kb) Multiome | 674 |
Genomic view of the TSC22D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.