This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for TRO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:54,639,123–54,640,128 | 281.1 kb | Distal (>10kb) Multiome | 686 | |
| chrX:54,807,568–54,809,334 | 112.1 kb | Distal (>10kb) Multiome | 567 | |
| chrX:54,920,679–54,921,069 | at TSS | At TSS | 130 | |
| chrX:54,921,216–54,922,087 | 991 bp | At TSS Multiome | 165 | |
| chrX:54,999,711–55,000,618 | 79.3 kb | Distal (>10kb) Multiome | 555 | |
| chrX:55,120,460–55,121,511 | 200.2 kb | Distal (>10kb) Multiome | 226 | |
| chrX:55,152,693–55,153,258 | 232.1 kb | Distal (>10kb) Multiome | 44 | |
| chrX:55,160,695–55,161,885 | 240.3 kb | Distal (>10kb) Multiome | 679 | |
| chrX:55,488,316–55,490,325 | 569.1 kb | Distal (>10kb) Multiome HiCAR | 373 |
Genomic view of the TRO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.