Enables tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRMT9B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT9B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT9B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:12,658,949–12,659,733 | 292.2 kb | Distal (>10kb) Multiome | 99 | |
| chr8:12,665,053–12,665,814 | 286.0 kb | Distal (>10kb) Multiome | 140 | |
| chr8:12,753,428–12,756,452 | 197.6 kb | Distal (>10kb) Multiome | 959 | |
| chr8:12,942,096–12,942,265 | 9.4 kb | Proximal (<10kb) | 39 | |
| chr8:12,942,371–12,942,923 | 8.7 kb | Proximal (<10kb) | 70 | |
| chr8:12,943,264–12,943,666 | 8.0 kb | Proximal (<10kb) | 15 | |
| chr8:12,951,067–12,952,574 | 169 bp | At TSS Multiome | 496 | |
| chr8:12,954,853–12,955,377 | 3.2 kb | Proximal (<10kb) | 14 | |
| chr8:12,972,190–12,973,116 | 20.9 kb | Distal (>10kb) Multiome | 182 | |
| chr8:13,041,246–13,042,612 | 90.0 kb | Distal (>10kb) Multiome | 464 | |
| chr8:13,059,354–13,060,646 | 108.3 kb | Distal (>10kb) Multiome | 365 | |
| chr8:13,081,802–13,082,427 | 130.5 kb | Distal (>10kb) Multiome | 66 | |
| chr8:13,105,620–13,106,699 | 154.5 kb | Distal (>10kb) Multiome | 247 | |
| chr8:13,121,610–13,122,407 | 170.4 kb | Distal (>10kb) Multiome | 170 | |
| chr8:13,131,138–13,134,186 | 180.1 kb | Distal (>10kb) Multiome | 823 |
Genomic view of the TRMT9B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.