This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for TRMT2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:100,791,389–100,792,153 | 260.3 kb | Distal (>10kb) Multiome | 74 | |
| chrX:100,819,952–100,820,670 | 231.8 kb | Distal (>10kb) Multiome | 553 | |
| chrX:100,928,599–100,929,634 | 123.0 kb | Distal (>10kb) Multiome | 309 | |
| chrX:101,051,311–101,052,275 | 215 bp | At TSS Multiome | 546 | |
| chrX:101,097,632–101,098,463 | 46.0 kb | Distal (>10kb) Multiome | 508 | |
| chrX:101,348,449–101,349,149 | 296.8 kb | Distal (>10kb) Multiome | 567 |
Genomic view of the TRMT2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.