Enables tRNA (guanosine(9)-N1)-methyltransferase activity. Involved in protein insertion into mitochondrial inner membrane. Located in cytosol and mitochondrial inner membrane. Part of TIM22 mitochondrial import inner membrane insertion complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRMT10B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT10B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT10B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:37,464,634–37,466,782 | 288.3 kb | Distal (>10kb) Multiome | 997 | |
| chr9:37,485,291–37,486,541 | 267.9 kb | Distal (>10kb) Multiome | 734 | |
| chr9:37,575,608–37,576,724 | 177.5 kb | Distal (>10kb) Multiome | 608 | |
| chr9:37,592,006–37,592,956 | 161.2 kb | Distal (>10kb) Multiome | 990 | |
| chr9:37,650,357–37,651,703 | 102.9 kb | Distal (>10kb) Multiome | 403 | |
| chr9:37,747,241–37,747,434 | 6.4 kb | Proximal (<10kb) | 197 | |
| chr9:37,749,045–37,749,333 | 4.5 kb | Proximal (<10kb) | 20 | |
| chr9:37,751,142–37,751,941 | 2.3 kb | Proximal (<10kb) Multiome | 38 | |
| chr9:37,753,624–37,754,122 | 39 bp | At TSS Multiome | 540 | |
| chr9:37,784,663–37,785,433 | 31.2 kb | Distal (>10kb) Multiome | 859 | |
| chr9:37,800,307–37,801,695 | 47.0 kb | Distal (>10kb) Multiome | 1104 | |
| chr9:37,903,405–37,904,985 | 150.4 kb | Distal (>10kb) Multiome | 1045 | |
| chr9:37,913,669–37,914,191 | 160.1 kb | Distal (>10kb) Multiome | 509 | |
| chr9:37,922,396–37,923,788 | 169.5 kb | Distal (>10kb) Multiome | 162 | |
| chr9:38,017,105–38,017,773 | 263.6 kb | Distal (>10kb) Multiome | 267 |
Genomic view of the TRMT10B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.