TRIR

telomerase RNA component interacting RNase | MGC2803, TERCIR, fSAP18, C19orf43

Enables 3'-5' exonuclease activity and 5'-3' exonuclease activity. Involved in rRNA catabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.26

Biological processes 8 terms

3'-5' exonuclease activity (GO:0008408)3'-5' exonuclease activity (GO:0008408)3'-5' exonuclease activity (GO:0008408)5'-3' exonuclease activity (GO:0008409)5'-3' exonuclease activity (GO:0008409)5'-3' exonuclease activity (GO:0008409)protein binding (GO:0005515)rRNA catabolic process (GO:0016075)

Expression (TPM)

TFs regulating TRIR 0 TFs

Transcription factors with Perturb-seq knockdown data for TRIR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TRIR

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,440,217–12,441,483	293.6 kb	Distal (>10kb) Multiome	565
chr19:12,484,131–12,485,387	249.9 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	239.2 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	183.1 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	163.0 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	123.8 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	94.4 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	86.9 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	77.5 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	67.9 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	65.1 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	53.2 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	38.0 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	31.4 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	12.2 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	10.6 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	85 bp	At TSS Multiome	882
chr19:12,736,470–12,737,780	2.5 kb	Proximal (<10kb) Multiome	742
chr19:12,757,454–12,758,297	23.1 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	31.6 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	40.8 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	43.2 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	48.1 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	55.4 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	56.9 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	59.0 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	67.3 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	71.9 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	91.2 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	98.0 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	99.3 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	103.8 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	106.2 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	113.1 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	133.0 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	138.7 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	146.8 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	150.7 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	156.4 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	178.7 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	184.7 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	199.1 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	203.8 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	211.3 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	222.6 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	230.8 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	249.0 kb	Distal (>10kb) Multiome	688

Genome Browser

Genomic view of the TRIR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.