This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for TRIML2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIML2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIML2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:187,995,145–187,996,086 | 114.0 kb | Distal (>10kb) Multiome | 219 | |
| chr4:188,031,743–188,032,849 | 77.2 kb | Distal (>10kb) Multiome | 242 | |
| chr4:188,107,786–188,108,710 | 1.3 kb | Proximal (<10kb) Multiome | 196 | |
| chr4:188,109,275–188,109,719 | at TSS | At TSS | 75 | |
| chr4:188,282,317–188,283,412 | 173.3 kb | Distal (>10kb) Multiome | 187 | |
| chr4:188,399,544–188,400,371 | 290.4 kb | Distal (>10kb) Multiome | 207 |
Genomic view of the TRIML2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.