The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for TRIM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,693,257–99,693,867 | 226.0 kb | Distal (>10kb) Multiome | 518 | |
| chr7:99,839,578–99,840,069 | 79.7 kb | Distal (>10kb) Multiome | 85 | |
| chr7:99,919,499–99,919,740 | at TSS | At TSS | 743 | |
| chr7:99,929,116–99,929,724 | 9.9 kb | Proximal (<10kb) Multiome | 300 | |
| chr7:100,015,387–100,016,069 | 96.1 kb | Distal (>10kb) Multiome | 744 | |
| chr7:100,049,441–100,050,060 | 130.3 kb | Distal (>10kb) Multiome | 800 | |
| chr7:100,081,134–100,083,000 | 162.3 kb | Distal (>10kb) Multiome | 1160 | |
| chr7:100,088,454–100,089,460 | 169.5 kb | Distal (>10kb) Multiome | 955 | |
| chr7:100,100,270–100,102,380 | 181.1 kb | Distal (>10kb) Multiome | 1102 | |
| chr7:100,119,029–100,120,415 | 200.0 kb | Distal (>10kb) Multiome | 954 | |
| chr7:100,126,675–100,128,006 | 207.7 kb | Distal (>10kb) Multiome | 919 | |
| chr7:100,148,262–100,149,663 | 229.3 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 239.2 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 247.9 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,167,894–100,168,793 | 249.1 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 252.0 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 258.0 kb | Distal (>10kb) Multiome | 626 |
Genomic view of the TRIM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.