The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRIM36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:115,161,067–115,161,519 | 8.3 kb | Proximal (<10kb) | 30 | |
| chr5:115,164,481–115,164,729 | 5.1 kb | Proximal (<10kb) | 2 | |
| chr5:115,169,002–115,171,603 | 195 bp | At TSS Multiome | 964 | |
| chr5:115,178,880–115,180,758 | 10.5 kb | Distal (>10kb) Multiome | 500 | |
| chr5:115,262,382–115,263,400 | 93.0 kb | Distal (>10kb) Multiome | 905 | |
| chr5:115,295,823–115,297,287 | 126.7 kb | Distal (>10kb) Multiome | 763 | |
| chr5:115,384,667–115,385,510 | 215.3 kb | Distal (>10kb) Multiome | 108 |
Genomic view of the TRIM36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.