The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRIM33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:114,287,494–114,287,999 | 223.5 kb | Distal (>10kb) Multiome | 32 | |
| chr1:114,345,893–114,347,057 | 164.5 kb | Distal (>10kb) Multiome | 785 | |
| chr1:114,510,080–114,511,643 | 36 bp | At TSS Multiome | 977 | |
| chr1:114,511,826–114,512,347 | 666 bp | At TSS | 268 | |
| chr1:114,581,305–114,582,040 | 70.5 kb | Distal (>10kb) Multiome | 796 | |
| chr1:114,642,026–114,643,180 | 131.4 kb | Distal (>10kb) Multiome | 125 | |
| chr1:114,669,579–114,670,824 | 158.9 kb | Distal (>10kb) Multiome | 605 | |
| chr1:114,716,313–114,717,190 | 205.7 kb | Distal (>10kb) Multiome | 869 | |
| chr1:114,756,971–114,758,310 | 246.7 kb | Distal (>10kb) Multiome | 1005 | |
| chr1:114,780,205–114,780,915 | 269.5 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the TRIM33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.