The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRIM32. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM32 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM32, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:115,494,943–115,495,875 | 1191.9 kb | Distal (>10kb) Multiome HiCAR | 383 | |
| chr9:116,686,450–116,688,091 | 13 bp | At TSS Multiome | 730 | |
| chr9:116,715,244–116,716,341 | 28.6 kb | Distal (>10kb) Multiome | 96 | |
| chr9:116,764,895–116,765,572 | 77.8 kb | Distal (>10kb) Multiome | 32 | |
| chr9:116,791,054–116,791,798 | 104.1 kb | Distal (>10kb) Multiome | 121 | |
| chr9:116,826,465–116,827,102 | 139.4 kb | Distal (>10kb) Multiome | 14 | |
| chr9:116,952,484–116,953,593 | 265.8 kb | Distal (>10kb) Multiome | 122 |
Genomic view of the TRIM32 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.