The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRIM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,234,062–6,235,769 | 239.0 kb | Distal (>10kb) Multiome | 776 | |
| chr11:6,258,709–6,260,456 | 214.2 kb | Distal (>10kb) Multiome | 283 | |
| chr11:6,318,947–6,321,304 | 154.6 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,353,367–6,353,932 | 120.3 kb | Distal (>10kb) Multiome | 395 | |
| chr11:6,389,605–6,390,990 | 83.5 kb | Distal (>10kb) Multiome | 752 | |
| chr11:6,405,086–6,405,670 | 68.5 kb | Distal (>10kb) Multiome | 99 | |
| chr11:6,418,399–6,419,618 | 54.9 kb | Distal (>10kb) Multiome | 494 | |
| chr11:6,468,896–6,469,642 | 4.6 kb | Proximal (<10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 150 bp | At TSS Multiome | 591 | |
| chr11:6,475,549–6,476,180 | 1.7 kb | Proximal (<10kb) | 94 | |
| chr11:6,480,885–6,482,114 | 7.5 kb | Proximal (<10kb) Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 23.4 kb | Distal (>10kb) Multiome | 71 | |
| chr11:6,586,489–6,587,591 | 113.1 kb | Distal (>10kb) Multiome | 231 | |
| chr11:6,603,192–6,604,726 | 129.8 kb | Distal (>10kb) Multiome | 908 | |
| chr11:6,606,600–6,607,433 | 133.2 kb | Distal (>10kb) Multiome | 532 | |
| chr11:6,611,505–6,613,097 | 138.4 kb | Distal (>10kb) Multiome | 996 | |
| chr11:6,618,753–6,619,738 | 145.6 kb | Distal (>10kb) Multiome | 587 | |
| chr11:6,629,672–6,631,067 | 156.6 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 181.9 kb | Distal (>10kb) Multiome | 314 | |
| chr11:6,682,693–6,683,793 | 209.5 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the TRIM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.