This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for TRAPPC6A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAPPC6A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAPPC6A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,890,209–44,891,796 | 287.3 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,903,686–44,904,241 | 274.4 kb | Distal (>10kb) Multiome | 666 | |
| chr19:44,905,114–44,907,037 | 271.5 kb | Distal (>10kb) Multiome | 645 | |
| chr19:44,913,546–44,915,671 | 263.1 kb | Distal (>10kb) Multiome | 587 | |
| chr19:44,926,693–44,927,388 | 251.0 kb | Distal (>10kb) Multiome | 277 | |
| chr19:44,954,641–44,955,824 | 223.0 kb | Distal (>10kb) Multiome | 835 | |
| chr19:45,001,031–45,002,639 | 176.9 kb | Distal (>10kb) Multiome | 694 | |
| chr19:45,038,879–45,039,566 | 139.1 kb | Distal (>10kb) Multiome | 800 | |
| chr19:45,075,125–45,076,814 | 101.7 kb | Distal (>10kb) Multiome | 710 | |
| chr19:45,078,897–45,080,647 | 98.1 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:45,091,042–45,093,574 | 85.2 kb | Distal (>10kb) Multiome | 959 | |
| chr19:45,177,803–45,179,711 | 256 bp | At TSS Multiome | 899 | |
| chr19:45,187,620–45,187,799 | 9.4 kb | Proximal (<10kb) | 150 | |
| chr19:45,234,200–45,234,822 | 56.3 kb | Distal (>10kb) Multiome | 105 | |
| chr19:45,250,821–45,251,491 | 73.0 kb | Distal (>10kb) Multiome | 397 | |
| chr19:45,340,431–45,341,201 | 162.6 kb | Distal (>10kb) Multiome | 363 | |
| chr19:45,370,064–45,371,122 | 192.4 kb | Distal (>10kb) Multiome | 592 | |
| chr19:45,402,280–45,402,828 | 224.3 kb | Distal (>10kb) Multiome | 332 | |
| chr19:45,403,781–45,404,684 | 225.8 kb | Distal (>10kb) Multiome | 494 | |
| chr19:45,404,818–45,406,887 | 228.3 kb | Distal (>10kb) Multiome | 964 | |
| chr19:45,423,326–45,424,545 | 245.5 kb | Distal (>10kb) Multiome | 996 | |
| chr19:45,439,539–45,440,189 | 261.6 kb | Distal (>10kb) Multiome | 718 | |
| chr19:45,443,052–45,444,768 | 265.3 kb | Distal (>10kb) Multiome | 857 | |
| chr19:45,450,695–45,451,265 | 272.6 kb | Distal (>10kb) Multiome | 515 | |
| chr19:45,455,706–45,456,201 | 277.7 kb | Distal (>10kb) Multiome | 776 | |
| chr19:45,467,169–45,468,696 | 289.5 kb | Distal (>10kb) Multiome | 686 | |
| chr19:45,468,843–45,470,312 | 291.2 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the TRAPPC6A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.