The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for TRAPPC11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAPPC11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAPPC11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:183,390,334–183,391,979 | 268.0 kb | Distal (>10kb) Multiome | 190 | |
| chr4:183,398,351–183,399,038 | 260.5 kb | Distal (>10kb) Multiome | 567 | |
| chr4:183,407,083–183,407,593 | 252.1 kb | Distal (>10kb) Multiome | 550 | |
| chr4:183,443,703–183,445,380 | 214.8 kb | Distal (>10kb) Multiome HiCAR | 1063 | |
| chr4:183,503,782–183,506,533 | 153.1 kb | Distal (>10kb) Multiome HiCAR | 969 | |
| chr4:183,658,630–183,659,843 | 93 bp | At TSS Multiome | 779 | |
| chr4:183,722,750–183,723,572 | 63.8 kb | Distal (>10kb) Multiome | 395 | |
| chr4:183,797,040–183,798,833 | 138.4 kb | Distal (>10kb) Multiome | 400 | |
| chr4:183,905,112–183,907,500 | 246.0 kb | Distal (>10kb) Multiome | 538 | |
| chr4:183,920,182–183,920,914 | 261.4 kb | Distal (>10kb) Multiome | 79 |
Genomic view of the TRAPPC11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.