The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for TRAF5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAF5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAF5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:211,133,108–211,134,829 | 192.6 kb | Distal (>10kb) Multiome | 739 | |
| chr1:211,222,016–211,223,252 | 104.2 kb | Distal (>10kb) Multiome | 343 | |
| chr1:211,258,333–211,261,113 | 67.6 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:211,323,167–211,323,875 | 3.0 kb | Proximal (<10kb) | 261 | |
| chr1:211,326,284–211,327,905 | 9 bp | At TSS Multiome | 543 | |
| chr1:211,375,133–211,375,818 | 48.6 kb | Distal (>10kb) Multiome | 107 | |
| chr1:211,382,531–211,383,307 | 56.0 kb | Distal (>10kb) Multiome | 921 | |
| chr1:211,398,188–211,399,458 | 72.0 kb | Distal (>10kb) Multiome | 128 | |
| chr1:211,399,597–211,400,219 | 73.3 kb | Distal (>10kb) Multiome | 80 | |
| chr1:211,416,272–211,417,162 | 89.8 kb | Distal (>10kb) Multiome | 257 | |
| chr1:211,469,768–211,470,490 | 143.4 kb | Distal (>10kb) Multiome HiCAR | 383 | |
| chr1:211,513,158–211,514,512 | 187.3 kb | Distal (>10kb) Multiome HiCAR | 484 | |
| chr1:211,515,159–211,516,023 | 188.8 kb | Distal (>10kb) Multiome HiCAR | 818 | |
| chr1:211,577,546–211,580,066 | 252.5 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:211,630,152–211,630,733 | 303.6 kb | Distal (>10kb) Multiome HiCAR | 515 | |
| chr1:211,655,045–211,655,900 | 328.6 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr1:211,667,030–211,667,875 | 340.6 kb | Distal (>10kb) Multiome HiCAR | 301 |
Genomic view of the TRAF5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.