This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRAF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,466,531–28,467,034 | 277.2 kb | Distal (>10kb) Multiome | 179 | |
| chr17:28,551,965–28,553,140 | 191.4 kb | Distal (>10kb) Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 172.5 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 167.1 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 144.9 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 121.7 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 98.8 kb | Distal (>10kb) Multiome | 795 | |
| chr17:28,661,635–28,662,527 | 81.9 kb | Distal (>10kb) Multiome | 809 | |
| chr17:28,710,720–28,712,813 | 32.6 kb | Distal (>10kb) Multiome | 892 | |
| chr17:28,717,030–28,718,784 | 26.2 kb | Distal (>10kb) Multiome | 492 | |
| chr17:28,718,918–28,720,313 | 24.3 kb | Distal (>10kb) Multiome | 927 | |
| chr17:28,724,652–28,729,474 | 17.0 kb | Distal (>10kb) Multiome | 1286 | |
| chr17:28,743,083–28,744,926 | 23 bp | At TSS Multiome | 991 | |
| chr17:28,745,076–28,746,436 | 1.6 kb | Proximal (<10kb) Multiome | 568 | |
| chr17:28,749,859–28,750,549 | 6.2 kb | Proximal (<10kb) Multiome | 550 | |
| chr17:28,811,615–28,812,945 | 68.5 kb | Distal (>10kb) Multiome | 699 | |
| chr17:28,842,307–28,843,098 | 98.7 kb | Distal (>10kb) Multiome | 717 | |
| chr17:28,854,460–28,855,289 | 110.9 kb | Distal (>10kb) Multiome HiCAR | 780 | |
| chr17:28,896,962–28,898,028 | 153.5 kb | Distal (>10kb) Multiome HiCAR | 846 | |
| chr17:28,902,302–28,903,488 | 159.0 kb | Distal (>10kb) Multiome HiCAR | 967 | |
| chr17:28,950,281–28,952,708 | 207.6 kb | Distal (>10kb) Multiome | 989 | |
| chr17:28,984,463–28,984,954 | 240.6 kb | Distal (>10kb) Multiome | 33 | |
| chr17:28,985,971–28,986,457 | 242.2 kb | Distal (>10kb) Multiome | 123 | |
| chr17:29,005,841–29,006,414 | 262.0 kb | Distal (>10kb) Multiome | 707 | |
| chr17:29,039,928–29,040,500 | 296.2 kb | Distal (>10kb) Multiome | 99 | |
| chr17:29,042,531–29,043,259 | 298.8 kb | Distal (>10kb) Multiome | 553 |
Genomic view of the TRAF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.