The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for TRAF3IP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAF3IP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAF3IP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:238,060,279–238,061,878 | 259.6 kb | Distal (>10kb) Multiome | 970 | |
| chr2:238,098,121–238,098,760 | 222.0 kb | Distal (>10kb) Multiome | 222 | |
| chr2:238,158,343–238,159,417 | 161.6 kb | Distal (>10kb) Multiome | 343 | |
| chr2:238,203,020–238,204,239 | 116.8 kb | Distal (>10kb) Multiome | 702 | |
| chr2:238,234,336–238,234,816 | 86.0 kb | Distal (>10kb) Multiome | 543 | |
| chr2:238,238,732–238,241,847 | 80.4 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:238,287,738–238,289,462 | 31.6 kb | Distal (>10kb) Multiome | 893 | |
| chr2:238,289,660–238,290,518 | 30.1 kb | Distal (>10kb) Multiome | 315 | |
| chr2:238,319,822–238,321,188 | 101 bp | At TSS Multiome | 623 | |
| chr2:238,425,866–238,427,628 | 106.4 kb | Distal (>10kb) Multiome | 920 |
Genomic view of the TRAF3IP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.