Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in negative regulation of Wnt signaling pathway and proteolysis. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRABD2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRABD2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRABD2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:84,855,538–84,856,452 | 25.1 kb | Distal (>10kb) Multiome | 137 | |
| chr2:84,879,622–84,881,453 | 20 bp | At TSS Multiome | 434 | |
| chr2:84,881,776–84,882,617 | 692 bp | At TSS | 438 | |
| chr2:84,904,641–84,908,593 | 24.5 kb | Distal (>10kb) Multiome | 1075 | |
| chr2:84,925,524–84,927,306 | 44.9 kb | Distal (>10kb) Multiome | 1034 | |
| chr2:84,957,753–84,958,825 | 77.2 kb | Distal (>10kb) Multiome | 500 | |
| chr2:84,959,740–84,960,486 | 79.0 kb | Distal (>10kb) Multiome | 381 | |
| chr2:84,970,310–84,972,229 | 90.0 kb | Distal (>10kb) Multiome | 809 | |
| chr2:85,066,689–85,067,387 | 186.0 kb | Distal (>10kb) Multiome | 352 | |
| chr2:85,119,847–85,120,292 | 239.0 kb | Distal (>10kb) Multiome | 127 | |
| chr2:85,132,493–85,135,747 | 254.1 kb | Distal (>10kb) Multiome | 660 | |
| chr2:85,178,933–85,179,785 | 298.2 kb | Distal (>10kb) Multiome | 95 |
Genomic view of the TRABD2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.