Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in post-translational protein modification. Located in Golgi membrane. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TPST1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPST1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPST1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:65,981,748–65,982,750 | 223.0 kb | Distal (>10kb) Multiome | 996 | |
| chr7:66,043,712–66,044,711 | 161.0 kb | Distal (>10kb) Multiome | 136 | |
| chr7:66,075,415–66,076,491 | 129.5 kb | Distal (>10kb) Multiome | 802 | |
| chr7:66,099,334–66,100,655 | 105.1 kb | Distal (>10kb) Multiome | 495 | |
| chr7:66,114,557–66,115,604 | 90.2 kb | Distal (>10kb) Multiome | 958 | |
| chr7:66,204,762–66,205,981 | 103 bp | At TSS Multiome | 816 | |
| chr7:66,413,302–66,414,074 | 208.4 kb | Distal (>10kb) Multiome | 440 | |
| chr7:66,493,259–66,494,185 | 288.4 kb | Distal (>10kb) Multiome | 849 |
Genomic view of the TPST1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.