This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for TPM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:14,571,772–14,572,330 | 1504.4 kb | Distal (>10kb) Multiome HiCAR | 896 | |
| chr19:14,689,407–14,690,497 | 1386.5 kb | Distal (>10kb) Multiome HiCAR | 624 | |
| chr19:14,979,199–14,980,219 | 1096.7 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr19:15,106,942–15,107,576 | 969.2 kb | Distal (>10kb) Multiome HiCAR | 339 | |
| chr19:15,113,323–15,113,828 | 962.9 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr19:15,418,493–15,419,441 | 657.3 kb | Distal (>10kb) Multiome HiCAR | 892 | |
| chr19:15,449,146–15,450,281 | 626.6 kb | Distal (>10kb) Multiome HiCAR | 446 | |
| chr19:16,075,837–16,077,586 | 81 bp | At TSS Multiome | 735 | |
| chr19:16,110,632–16,112,318 | 35.2 kb | Distal (>10kb) Multiome | 866 | |
| chr19:16,184,971–16,186,029 | 108.9 kb | Distal (>10kb) Multiome | 658 | |
| chr19:16,197,472–16,198,501 | 121.4 kb | Distal (>10kb) Multiome | 806 | |
| chr19:16,247,463–16,247,928 | 171.3 kb | Distal (>10kb) Multiome | 370 | |
| chr19:16,324,466–16,326,401 | 249.6 kb | Distal (>10kb) Multiome | 477 |
Genomic view of the TPM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.