This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]
Transcription factors with Perturb-seq knockdown data for TPM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:63,041,931–63,043,171 | 98 bp | At TSS Multiome | 510 | |
| chr15:63,047,449–63,049,284 | 5.8 kb | Proximal (<10kb) Multiome | 977 | |
| chr15:63,052,986–63,053,551 | 10.8 kb | Distal (>10kb) Multiome | 265 | |
| chr15:63,121,504–63,122,682 | 79.3 kb | Distal (>10kb) Multiome | 750 | |
| chr15:63,157,102–63,158,166 | 114.9 kb | Distal (>10kb) Multiome | 954 | |
| chr15:63,188,797–63,190,016 | 146.8 kb | Distal (>10kb) Multiome | 573 | |
| chr15:63,277,063–63,278,175 | 234.8 kb | Distal (>10kb) Multiome | 651 |
Genomic view of the TPM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.