Predicted to enable microtubule binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including adult behavior; chemical synaptic transmission; and protein polyglutamylation. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TPGS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPGS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPGS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:289,719–291,481 | 217.0 kb | Distal (>10kb) Multiome | 412 | |
| chr19:294,836–295,426 | 212.2 kb | Distal (>10kb) Multiome | 231 | |
| chr19:343,939–345,411 | 162.7 kb | Distal (>10kb) Multiome HiCAR | 600 | |
| chr19:408,569–409,459 | 98.4 kb | Distal (>10kb) Multiome | 310 | |
| chr19:459,789–461,382 | 47.3 kb | Distal (>10kb) Multiome | 545 | |
| chr19:461,557–462,453 | 45.5 kb | Distal (>10kb) Multiome | 580 | |
| chr19:488,399–489,918 | 18.4 kb | Distal (>10kb) Multiome | 898 | |
| chr19:506,451–508,366 | 332 bp | At TSS Multiome | 1001 | |
| chr19:510,509–511,797 | 3.4 kb | Proximal (<10kb) Multiome | 739 | |
| chr19:518,865–519,356 | 11.6 kb | Distal (>10kb) Multiome | 151 | |
| chr19:530,809–533,397 | 23.9 kb | Distal (>10kb) Multiome | 856 | |
| chr19:572,071–573,594 | 65.0 kb | Distal (>10kb) Multiome | 888 | |
| chr19:588,127–589,976 | 80.8 kb | Distal (>10kb) Multiome | 526 | |
| chr19:632,653–633,806 | 126.1 kb | Distal (>10kb) Multiome | 758 | |
| chr19:639,456–640,331 | 132.3 kb | Distal (>10kb) Multiome | 389 | |
| chr19:662,267–663,864 | 155.8 kb | Distal (>10kb) Multiome | 723 | |
| chr19:679,616–681,731 | 173.2 kb | Distal (>10kb) Multiome | 832 | |
| chr19:703,387–704,718 | 196.5 kb | Distal (>10kb) Multiome | 586 | |
| chr19:708,425–709,293 | 201.3 kb | Distal (>10kb) Multiome | 317 | |
| chr19:796,668–798,362 | 289.7 kb | Distal (>10kb) Multiome | 956 |
Genomic view of the TPGS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.