This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for TPD52L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPD52L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPD52L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:124,961,736–124,963,798 | 191.6 kb | Distal (>10kb) Multiome HiCAR | 660 | |
| chr6:125,099,255–125,100,053 | 54.1 kb | Distal (>10kb) Multiome | 540 | |
| chr6:125,153,568–125,155,310 | 1.2 kb | Proximal (<10kb) Multiome | 927 | |
| chr6:125,301,431–125,302,347 | 148.1 kb | Distal (>10kb) Multiome | 1009 | |
| chr6:125,363,077–125,364,300 | 210.0 kb | Distal (>10kb) Multiome | 554 | |
| chr6:125,421,627–125,422,704 | 268.3 kb | Distal (>10kb) Multiome | 252 | |
| chr6:125,780,157–125,781,423 | 626.6 kb | Distal (>10kb) Multiome HiCAR | 1022 | |
| chr6:125,986,066–125,987,257 | 832.8 kb | Distal (>10kb) Multiome HiCAR | 925 |
Genomic view of the TPD52L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.