Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TP53RK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TP53RK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TP53RK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:46,405,903–46,407,320 | 282.9 kb | Distal (>10kb) Multiome | 946 | |
| chr20:46,459,001–46,459,476 | 230.2 kb | Distal (>10kb) Multiome | 157 | |
| chr20:46,513,244–46,513,752 | 175.9 kb | Distal (>10kb) Multiome HiCAR | 458 | |
| chr20:46,562,567–46,563,148 | 126.6 kb | Distal (>10kb) Multiome HiCAR | 483 | |
| chr20:46,583,359–46,584,278 | 105.7 kb | Distal (>10kb) Multiome HiCAR | 196 | |
| chr20:46,648,981–46,649,761 | 40.2 kb | Distal (>10kb) Multiome | 275 | |
| chr20:46,651,152–46,651,711 | 38.0 kb | Distal (>10kb) Multiome | 558 | |
| chr20:46,681,460–46,681,632 | 7.8 kb | Proximal (<10kb) | 360 | |
| chr20:46,683,782–46,684,167 | 5.3 kb | Proximal (<10kb) | 253 | |
| chr20:46,688,904–46,689,939 | 126 bp | At TSS Multiome | 940 | |
| chr20:46,709,122–46,710,092 | 20.3 kb | Distal (>10kb) Multiome | 652 | |
| chr20:46,814,576–46,815,121 | 125.4 kb | Distal (>10kb) Multiome | 272 | |
| chr20:46,894,554–46,895,109 | 205.3 kb | Distal (>10kb) Multiome | 179 | |
| chr20:46,898,312–46,898,778 | 209.0 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the TP53RK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.