Enables ATP hydrolysis activity. Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TOR3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOR3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOR3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:179,002,311–179,003,353 | 79.2 kb | Distal (>10kb) Multiome | 522 | |
| chr1:179,025,292–179,027,102 | 56.1 kb | Distal (>10kb) Multiome | 930 | |
| chr1:179,079,042–179,079,618 | 2.5 kb | Proximal (<10kb) | 164 | |
| chr1:179,081,467–179,083,301 | 39 bp | At TSS Multiome | 968 | |
| chr1:179,087,385–179,088,206 | 5.8 kb | Proximal (<10kb) Multiome | 194 | |
| chr1:179,228,751–179,230,142 | 147.7 kb | Distal (>10kb) Multiome HiCAR | 634 | |
| chr1:179,293,131–179,294,199 | 211.7 kb | Distal (>10kb) Multiome | 884 | |
| chr1:179,365,435–179,366,459 | 283.8 kb | Distal (>10kb) Multiome HiCAR | 811 | |
| chr1:179,591,348–179,592,445 | 509.8 kb | Distal (>10kb) Multiome HiCAR | 401 | |
| chr1:179,702,681–179,703,716 | 621.1 kb | Distal (>10kb) Multiome HiCAR | 163 | |
| chr1:179,814,386–179,815,656 | 732.9 kb | Distal (>10kb) Multiome HiCAR | 543 |
Genomic view of the TOR3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.