This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis of atherosclerosis. The antimicrobial peptide salusin-beta has antibacterial activity. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for TOR2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOR2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOR2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,450,607–127,452,473 | 283.9 kb | Distal (>10kb) Multiome | 1009 | |
| chr9:127,567,936–127,569,972 | 166.1 kb | Distal (>10kb) Multiome | 660 | |
| chr9:127,608,129–127,608,913 | 126.7 kb | Distal (>10kb) Multiome HiCAR | 700 | |
| chr9:127,611,734–127,612,761 | 123.1 kb | Distal (>10kb) Multiome | 566 | |
| chr9:127,699,155–127,699,632 | 35.8 kb | Distal (>10kb) Multiome | 440 | |
| chr9:127,715,013–127,716,345 | 19.5 kb | Distal (>10kb) Multiome | 735 | |
| chr9:127,734,444–127,735,606 | 8 bp | At TSS Multiome | 836 | |
| chr9:127,741,739–127,743,092 | 7.6 kb | Proximal (<10kb) Multiome | 367 | |
| chr9:127,754,123–127,755,506 | 20.1 kb | Distal (>10kb) Multiome | 279 | |
| chr9:127,770,807–127,771,925 | 36.2 kb | Distal (>10kb) Multiome | 550 | |
| chr9:127,784,682–127,787,009 | 51.3 kb | Distal (>10kb) Multiome | 858 | |
| chr9:127,802,385–127,803,632 | 67.7 kb | Distal (>10kb) Multiome | 867 | |
| chr9:127,809,338–127,810,272 | 74.6 kb | Distal (>10kb) Multiome | 276 | |
| chr9:127,825,222–127,826,046 | 90.4 kb | Distal (>10kb) Multiome | 451 | |
| chr9:127,828,234–127,829,024 | 93.3 kb | Distal (>10kb) Multiome | 521 | |
| chr9:127,877,282–127,878,202 | 142.5 kb | Distal (>10kb) Multiome | 531 | |
| chr9:127,897,316–127,897,796 | 162.2 kb | Distal (>10kb) Multiome | 437 | |
| chr9:127,898,861–127,900,094 | 164.3 kb | Distal (>10kb) Multiome | 630 | |
| chr9:127,916,386–127,917,505 | 181.8 kb | Distal (>10kb) Multiome HiCAR | 474 | |
| chr9:127,926,756–127,928,574 | 192.3 kb | Distal (>10kb) Multiome | 411 | |
| chr9:127,930,321–127,931,068 | 195.5 kb | Distal (>10kb) Multiome | 537 | |
| chr9:127,937,578–127,938,244 | 202.6 kb | Distal (>10kb) Multiome | 674 | |
| chr9:127,955,445–127,955,915 | 220.3 kb | Distal (>10kb) Multiome | 540 | |
| chr9:127,980,172–127,981,966 | 245.8 kb | Distal (>10kb) Multiome | 691 | |
| chr9:128,033,544–128,034,106 | 298.6 kb | Distal (>10kb) Multiome | 69 | |
| chr9:128,034,940–128,035,527 | 300.1 kb | Distal (>10kb) Multiome | 480 |
Genomic view of the TOR2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.