This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for TOR1AIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOR1AIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOR1AIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:179,586,188–179,586,937 | 296.2 kb | Distal (>10kb) Multiome | 413 | |
| chr1:179,591,348–179,592,445 | 290.8 kb | Distal (>10kb) Multiome | 401 | |
| chr1:179,702,681–179,703,716 | 179.5 kb | Distal (>10kb) Multiome | 163 | |
| chr1:179,742,680–179,744,798 | 139.5 kb | Distal (>10kb) Multiome | 322 | |
| chr1:179,788,146–179,788,608 | 94.2 kb | Distal (>10kb) Multiome | 55 | |
| chr1:179,814,386–179,815,656 | 67.7 kb | Distal (>10kb) Multiome | 543 | |
| chr1:179,877,712–179,878,194 | 4.8 kb | Proximal (<10kb) Multiome | 604 | |
| chr1:179,881,882–179,883,626 | 57 bp | At TSS Multiome | 1162 | |
| chr1:179,883,888–179,884,046 | 1.2 kb | Proximal (<10kb) | 86 | |
| chr1:179,954,005–179,955,565 | 72.0 kb | Distal (>10kb) Multiome | 988 | |
| chr1:180,154,067–180,155,804 | 272.1 kb | Distal (>10kb) Multiome | 774 | |
| chr1:180,167,793–180,168,531 | 285.5 kb | Distal (>10kb) Multiome | 388 |
Genomic view of the TOR1AIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.