This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for TOP1MT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOP1MT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOP1MT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:143,266,869–143,267,949 | 67.5 kb | Distal (>10kb) Multiome | 733 | |
| chr8:143,290,813–143,291,709 | 43.5 kb | Distal (>10kb) Multiome | 909 | |
| chr8:143,334,216–143,335,267 | 14 bp | At TSS Multiome | 688 | |
| chr8:143,368,147–143,369,893 | 33.9 kb | Distal (>10kb) Multiome | 698 | |
| chr8:143,407,212–143,408,612 | 73.2 kb | Distal (>10kb) Multiome | 447 | |
| chr8:143,428,968–143,431,754 | 96.0 kb | Distal (>10kb) Multiome | 743 | |
| chr8:143,540,714–143,542,061 | 206.6 kb | Distal (>10kb) Multiome | 849 | |
| chr8:143,553,122–143,554,177 | 218.8 kb | Distal (>10kb) Multiome | 775 | |
| chr8:143,558,225–143,558,936 | 223.6 kb | Distal (>10kb) Multiome | 600 | |
| chr8:143,567,166–143,570,227 | 234.3 kb | Distal (>10kb) Multiome | 485 | |
| chr8:143,571,367–143,572,283 | 236.9 kb | Distal (>10kb) Multiome | 443 | |
| chr8:143,577,641–143,578,799 | 243.5 kb | Distal (>10kb) Multiome | 470 | |
| chr8:143,596,744–143,599,643 | 262.7 kb | Distal (>10kb) Multiome | 973 | |
| chr8:143,608,979–143,610,357 | 274.9 kb | Distal (>10kb) Multiome | 735 | |
| chr8:143,617,068–143,618,380 | 282.8 kb | Distal (>10kb) Multiome | 823 |
Genomic view of the TOP1MT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.