This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for TOB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:50,586,525–50,587,142 | 279.6 kb | Distal (>10kb) Multiome | 43 | |
| chr17:50,634,652–50,635,325 | 231.3 kb | Distal (>10kb) Multiome | 471 | |
| chr17:50,707,179–50,708,006 | 158.7 kb | Distal (>10kb) Multiome | 1055 | |
| chr17:50,719,167–50,720,018 | 146.8 kb | Distal (>10kb) Multiome | 1050 | |
| chr17:50,864,985–50,865,141 | 1.2 kb | Proximal (<10kb) | 281 | |
| chr17:50,865,239–50,868,097 | 99 bp | At TSS Multiome | 1256 | |
| chr17:50,905,047–50,905,768 | 39.2 kb | Distal (>10kb) Multiome | 556 | |
| chr17:50,931,004–50,931,866 | 64.9 kb | Distal (>10kb) Multiome HiCAR | 780 | |
| chr17:50,944,102–50,945,190 | 78.3 kb | Distal (>10kb) Multiome HiCAR | 985 | |
| chr17:50,950,043–50,950,638 | 84.2 kb | Distal (>10kb) Multiome HiCAR | 713 | |
| chr17:51,119,858–51,121,548 | 254.6 kb | Distal (>10kb) Multiome | 961 | |
| chr17:51,153,226–51,154,064 | 287.1 kb | Distal (>10kb) Multiome | 1231 | |
| chr17:51,165,369–51,167,398 | 300.0 kb | Distal (>10kb) Multiome | 1044 |
Genomic view of the TOB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.