Transcription factors with Perturb-seq knockdown data for TNRC18P1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNRC18P1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNRC18P1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:140,635,760–140,635,930 | 9.6 kb | Proximal (<10kb) | 253 | |
| chr4:140,637,946–140,638,131 | 7.4 kb | Proximal (<10kb) | 110 | |
| chr4:140,640,083–140,640,873 | 4.6 kb | Proximal (<10kb) | 115 | |
| chr4:140,641,747–140,642,552 | 2.9 kb | Proximal (<10kb) | 293 | |
| chr4:140,653,633–140,654,475 | 8.1 kb | Proximal (<10kb) | 104 |
Genomic view of the TNRC18P1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.