This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for TNFRSF1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFRSF1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFRSF1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,056,451–6,057,152 | 285.4 kb | Distal (>10kb) Multiome | 147 | |
| chr12:6,124,068–6,125,228 | 217.4 kb | Distal (>10kb) Multiome | 240 | |
| chr12:6,199,391–6,201,130 | 141.8 kb | Distal (>10kb) Multiome | 481 | |
| chr12:6,214,773–6,215,509 | 126.8 kb | Distal (>10kb) Multiome | 158 | |
| chr12:6,278,466–6,279,375 | 63.3 kb | Distal (>10kb) Multiome | 655 | |
| chr12:6,310,091–6,311,512 | 31.4 kb | Distal (>10kb) Multiome | 645 | |
| chr12:6,322,926–6,323,961 | 18.7 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,329,238–6,330,028 | 12.5 kb | Distal (>10kb) Multiome | 135 | |
| chr12:6,335,766–6,337,493 | 5.5 kb | Proximal (<10kb) Multiome | 962 | |
| chr12:6,341,619–6,342,234 | 104 bp | At TSS Multiome | 657 | |
| chr12:6,342,478–6,342,614 | 393 bp | At TSS | 65 | |
| chr12:6,363,292–6,364,138 | 21.5 kb | Distal (>10kb) Multiome | 718 | |
| chr12:6,370,899–6,371,535 | 29.2 kb | Distal (>10kb) Multiome | 572 | |
| chr12:6,375,204–6,377,302 | 33.4 kb | Distal (>10kb) Multiome | 601 | |
| chr12:6,383,790–6,384,442 | 42.0 kb | Distal (>10kb) Multiome | 812 | |
| chr12:6,451,305–6,451,838 | 109.3 kb | Distal (>10kb) Multiome | 535 | |
| chr12:6,469,922–6,471,399 | 128.8 kb | Distal (>10kb) Multiome | 930 | |
| chr12:6,492,998–6,494,331 | 151.2 kb | Distal (>10kb) Multiome | 936 | |
| chr12:6,533,253–6,535,726 | 192.2 kb | Distal (>10kb) Multiome | 1131 | |
| chr12:6,539,914–6,540,883 | 198.6 kb | Distal (>10kb) Multiome | 427 | |
| chr12:6,554,111–6,554,621 | 212.2 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,555,532–6,556,318 | 214.0 kb | Distal (>10kb) Multiome | 551 | |
| chr12:6,567,822–6,568,719 | 226.3 kb | Distal (>10kb) Multiome | 837 | |
| chr12:6,605,947–6,607,790 | 265.4 kb | Distal (>10kb) Multiome | 774 | |
| chr12:6,613,155–6,614,551 | 272.0 kb | Distal (>10kb) Multiome | 810 | |
| chr12:6,620,128–6,620,868 | 278.4 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the TNFRSF1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.