The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for TMTC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMTC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMTC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:82,424,865–82,427,240 | 260.4 kb | Distal (>10kb) Multiome | 262 | |
| chr12:82,682,443–82,682,660 | 4.2 kb | Proximal (<10kb) | 73 | |
| chr12:82,685,588–82,688,470 | 783 bp | At TSS Multiome | 838 | |
| chr12:82,695,608–82,695,884 | 8.7 kb | Proximal (<10kb) | 17 | |
| chr12:82,756,363–82,756,918 | 69.7 kb | Distal (>10kb) Multiome | 185 | |
| chr12:82,802,846–82,803,994 | 116.5 kb | Distal (>10kb) Multiome | 169 | |
| chr12:83,470,689–83,471,772 | 784.1 kb | Distal (>10kb) Multiome HiCAR | 188 | |
| chr12:83,823,450–83,824,213 | 1136.9 kb | Distal (>10kb) Multiome HiCAR | 304 | |
| chr12:84,270,129–84,271,448 | 1583.9 kb | Distal (>10kb) Multiome HiCAR | 194 |
Genomic view of the TMTC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.