Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMTC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMTC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMTC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:29,640,567–29,641,500 | 143.0 kb | Distal (>10kb) Multiome | 109 | |
| chr12:29,691,131–29,691,761 | 92.5 kb | Distal (>10kb) Multiome | 172 | |
| chr12:29,782,690–29,784,855 | 38 bp | At TSS Multiome | 488 | |
| chr12:29,991,963–29,993,063 | 208.6 kb | Distal (>10kb) Multiome | 128 | |
| chr12:30,794,833–30,797,324 | 1011.4 kb | Distal (>10kb) Multiome HiCAR | 731 |
Genomic view of the TMTC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.